Potassium-Incorporated Titanium Oxide Nanoparticles Modulate Human Dendritic Cell Immune Response to Mycobacterium leprae
نویسندگان
چکیده
The two polar clinical forms of leprosy, termed tuberculoid and lepromatous, have polarized cellular immune responses with complex immunological distinctions. predominance DCs in leprosy has been reported, while the lepromatous pattern illness is associated weak activation local populations DCs. TiO2 nanoparticles previously shown to induce maturation these cells, leading an inflammatory response similar adjuvant usage vaccine administration. We aimed evaluate effect potassium-incorporated Ti oxide nanostructures, namely KTiOxs, human monocyte-derived live M. leprae. Human monocytic cell line dual THP-1, which harbors inducible reporter plasmid systems for transcription factor NF-κB interferon regulating (IRF), was treated titanium control or 1 mol/L KOH-treated 10 KOH 24 h. Subsequently, cells were infected KTiOx increase DC phagocytic activity without inflammation. exposure led IRF modulation It also differential secretion critical components innate development cell-mediated immunity against intracellular pathogens. This study demonstrates nanostructures KTiOxs usefulness nanoparticle technology vitro infectious disease a puzzling spectrum. Our findings may prompt future therapeutic strategies, such as immunotherapy disseminated progressive lesions.
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ژورنال
عنوان ژورنال: Microbiology research
سال: 2023
ISSN: ['2036-7473', '2036-7481']
DOI: https://doi.org/10.3390/microbiolres14020055